
A | Eknath Shinde was welcomed with much pomp and show on his first visit to his home district of Thane since becoming Maharashtra's state chief on Thursday.,The wife of the legislator from Kopri-Pachpakhadi constituency of Thane district, adjoining state capital Mumbai, was seen playing drums outside their residence in a video that has gone viral online.,According to Indian media, Lata Shinde played a key role in her husband Eknath's rise as a politician, who had been the de-facto No.2 in Shiv Sena.,Wife of #Maharashtra CM #EknathShinde, #LataShinde, played drums to welcome him in Thane. pic.twitter.com/u1ggibf7SN— Talora Maahi (@TaloraMaahi) July 6, 2022,Eknath worked as an autorickshaw driver before starting his political innings with Shiv Sena in the 1990s. Subsequently, he was named the Thane District chief by the party in 2005 after being elected to the Maharashtra state assembly the previous year.Since 2004, the 58-year-old politician won four consecutive elections in Kopri-Pachpakhadi and served as the leader of the opposition and minister in back-to-back governments before taking charge as the state chief earlier this month.His elevation to the state's top post came after he rebelled against his own party boss Uddhav Thackeray last month, taking away a large chunk of legislators along with him, first to Gujarat state and then Assam state. Both are federally governing Bharatiya Janata Party (BJP)-led states.On Monday, Eknath won a crucial vote of confidence to prove his government's majority in the state assembly with the help of the BJP, which has 106 lawmakers in Maharashtra.Last night, he went on his maiden visit to Thane after being made state chief. When he reached the Anand Nagar area of the city, a large crowd showered him with flower petals.Shinde's show of strength in Thane appears to be a signal to his predecessor and Shiv Sena chief Uddhav Thackeray that his revolt against him has been endorsed by the state's electorate.,Want to know more? Check out our Koo & Telegram accounts!,Koo: https://www.kooapp.com/profile/sputniknews,Sputnik India: https://t.me/sputniknewsindia。 2026年8月19日,美国生物技术公司Moderna与制药巨头默沙东(Merck)联合公布了个性化mRNA癌症疫苗intismeran autogene的III期临床试验积极结果。试验数据显示,该疫苗与免疫疗法药物Keytruda(帕博利珠单抗)联合使用,可显著降低高风险黑色素瘤患者的复发或死亡风险。

B | 该试验涉及超过1000名已接受肿瘤切除手术的高风险黑色素瘤患者。

C | 需要指出的是,由于该疫苗是根据每位患者肿瘤DNA个性化定制的,因此无法在癌症发生前起到预防作用,其目标是尽可能让癌症不再复发,属于治疗性疫苗而非预防性疫苗。具体流程为:手术切除肿瘤后对其DNA进行测序,AI算法从数百个突变中筛选出最多34个最可能激发免疫反应的新抗原,随后自动化软件将这些基因标记转化为mRNA指令,制造出教导患者免疫系统攻击对应癌细胞的疫苗。

D | 特斯拉、SpaceX首席执行官埃隆·马斯克在社交平台对此事表态称:"尽管mRNA在新冠疫情期间被明显滥用,但它在治愈疾病方面具有巨大的潜力。

E | 人工RNA本质上使治愈疾病变成了一个软件问题。

F | "此前,人工智能公司Anthropic首席执行官达里奥·阿莫迪曾表示,AI公司必须通过"真正治愈癌症"等切实成果来赢得公众信任,而不是依赖乐观的营销宣传。

G | 对此,马斯克于8月18日回应称:"AI会做到。"马斯克长期以来一直将人工智能视为医疗变革的关键路径。他曾表示,特斯拉的Optimus人形机器人与人工智能相结合,"将实现比任何人当前所获得的更好的医疗保健",并声称Optimus将在三年内超越世界上最好的人类外科医生。 市场方面,Moderna股价在该消息公布后大幅飙升。高盛预测,该疗法在黑色素瘤领域的全球销售峰值将达到43亿美元,在非小细胞肺癌领域将达到66亿美元。除黑色素瘤外,Moderna还正与默沙东进行更多试验,评估该疫苗与Keytruda及其他抗癌疗法联合用于肺癌、膀胱癌和肾癌等多种肿瘤类型的疗效。不过,也有分析人士保持谨慎。花旗分析师指出,由于缺乏完整数据集,目前尚难以评估辅助治疗黑色素瘤的疗效程度、持久性和商业价值。

H | 此外,个性化定制的商业化门槛高、规模化生产成本昂贵、跨癌种疗效尚待验证,这些都是从"临床成功"走向"商业成功"必须跨越的障碍。本文由游民星空制作发布,未经允许禁止转载。
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